MOLECULAR STUDY THE EFFECT OF FUCUS VESICULOSUS ON PITUITARY GLAND AND THYROID GLAND IN MALE RATS TREATED WITH PROPYLTHIOURACIL

Abstract

The present study aims to identify the effects of the fucus vesiculosus on the TSH expression in the tissue of pituitary gland of mature male rats treated with Propylthiouracil (PTU). The sample is divided into five groups in addition to the control group. All groups are equal in number where each group includes ten rats. The control group has been given distilled water. The first treatment (T1): fucus vesiculosus of 35 mg/ kg concentration of body weight is given, (T2): propylthiouracil (PTU) of 15 mg/kg concentration of body weight is dosed, (T3): fucus vesiculosus of 35 mg/ kg concentration of body weight is given for three weeks then (PTU) of 15 mg/kg concentration is dosed for the other three weeks, (T4): propylthiouracil (PTU) of 15 mg/kg concentration of body weight is dosed for three weeks then fucus vesiculosus of 35 mg/ kg concentration of body weight is given for three weeks and in (T5) fucus vesiculosus and (PTU) are dosed together with the same concentration for 42 days.