THE LEVEL OF SERUM ADIPONECTIN AND ITS POSSIBLE ROLE IN RHEUMATOID ARTHRITIS PATIENTS

Abstract

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that damages joints and impairs daily life for those affected. RA is caused on by three risk factors: genetics, gender, and smoking. Factors such as pro-inflammatory chemicals, insulin resistance, total oxidant status, adhesion molecules and the use of corticosteroids in chronic inflammatory disorders also contribute to the acceleration of atherosclerosis. Adipose tissue plays an important role in maintaining overall body balance. There are numerous bioactive peptides known as adipo(cyto)kines secreted by adipocytes. Adiponectin, the most common adipokine produced by adipose tissue, has anti-atherogenic properties. Adiponectin has 244 amino acids and is an abundant protein hormone. Recent study suggests that adiponectin may be useful in the diagnosis of RA and other rheumatic diseases.